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The D. melanogaster gene Epidermal growth factor receptor, abbreviated as Egfr, is reported here. It has also been known in FlyBase as HD-33 and l(2)05351. It encodes a product with epidermal growth factor receptor activity involved in eye morphogenesis (sensu Drosophila) which is a component of the integral to plasma membrane; it is expressed in the adult (cerebral cortex, follicle cell, proventriculus and thoracic ganglion), embryo (apodeme, cellular blastoderm, celular blastoderm, cephalic furrow and 19 other listed tissues), larva (Malpighian tubule, antennal disc, dorsal mesothoracic disc, embryonic/larval salivary gland and 15 other listed tissues), ovary (follicle cell, nurse cell and oocyte) and prepupa and pupa (adult foregut, adult hindgut and adult fat body). It has been sequenced and its amino acid sequence contains an epidermal growth-factor receptor (EGFR), L domain, an eukaryotic protein kinase, a tyrosine kinase catalytic domain and a furin-like cysteine rich region. It has been mapped by recombination to 2-101 and cytologically to 57E9--F1. It interacts genetically with vn, ed, N, rho, Ras85D and 81 other listed genes. There are 139 recorded alleles: 27 in vitro constructs (2 available from the public stock centers), 111 classical mutants (6 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the somatic clone wing, the somatic clone leg, the somatic clone head and 8 other listed tissues and are embryonic recessive lethal, partially somatic clone cell lethal and recessive visible. Egfr is discussed in 835 references (excluding sequence accessions), dated between 1960 and 2004. These include at least 136 studies of mutant phenotypes, 33 studies of wild-type function and 15 molecular studies. Among findings on Egfr mutants, Egfr is necessary for proper wing venation, development of the arista, legs and female genital disc and mutations alter the distribution of macrochaetae. Among findings on Egfr function, Egfr signalling regulates ommatidial rotation and cell motility in the eye. (However, there is much more information on function so that may not be representative.)
FBrf0155681
Affolter et al.
2003
Dev. Cell 4(1): 11--18Tube or not tube. Remodeling epithelial tissues by branching morphogenesis.
Review
Reference:
FBrf0158927
Shilo
2003
Exp. Cell Res. 284(1): 140--149Signaling by the Drosophila epidermal growth factor receptor pathway during development.
Review
Reference:
FBrf0158727
de Celis
2003
BioEssays 25(5): 443--451Pattern formation in the Drosophila wing: the development of the veins.
Review
SUMMARY
The D. melanogaster gene Epidermal growth factor receptor, abbreviated as Egfr, is reported here. It has also been known in FlyBase as HD-33 and l(2)05351. It encodes a product with epidermal growth factor receptor activity involved in eye morphogenesis (sensu Drosophila) which is a component of the integral to plasma membrane; it is expressed in the adult (cerebral cortex, follicle cell, proventriculus and thoracic ganglion), embryo (apodeme, cellular blastoderm, celular blastoderm, cephalic furrow and 19 other listed tissues), larva (Malpighian tubule, antennal disc, dorsal mesothoracic disc, embryonic/larval salivary gland and 15 other listed tissues), ovary (follicle cell, nurse cell and oocyte) and prepupa and pupa (adult foregut, adult hindgut and adult fat body). It has been sequenced and its amino acid sequence contains an epidermal growth-factor receptor (EGFR), L domain, an eukaryotic protein kinase, a tyrosine kinase catalytic domain and a furin-like cysteine rich region. It has been mapped by recombination to 2-101 and cytologically to 57E9--F1. It interacts genetically with vn, ed, N, rho, Ras85D and 81 other listed genes. There are 139 recorded alleles: 27 in vitro constructs (2 available from the public stock centers), 111 classical mutants (6 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the somatic clone wing, the somatic clone leg, the somatic clone head and 8 other listed tissues and are embryonic recessive lethal, partially somatic clone cell lethal and recessive visible. Egfr is discussed in 835 references (excluding sequence accessions), dated between 1960 and 2004. These include at least 136 studies of mutant phenotypes, 33 studies of wild-type function and 15 molecular studies. Among findings on Egfr mutants, Egfr is necessary for proper wing venation, development of the arista, legs and female genital disc and mutations alter the distribution of macrochaetae. Among findings on Egfr function, Egfr signalling regulates ommatidial rotation and cell motility in the eye. (However, there is much more information on function so that may not be representative.)
FBrf0155681
Affolter et al.
2003
Dev. Cell 4(1): 11--18Tube or not tube. Remodeling epithelial tissues by branching morphogenesis.
Review
Reference:
FBrf0158927
Shilo
2003
Exp. Cell Res. 284(1): 140--149Signaling by the Drosophila epidermal growth factor receptor pathway during development.
Review
Reference:
FBrf0158727
de Celis
2003
BioEssays 25(5): 443--451Pattern formation in the Drosophila wing: the development of the veins.
Review
SUMMARY
The D. melanogaster gene Epidermal growth factor receptor, abbreviated as Egfr, is reported here. It has also been known in FlyBase as HD-33 and l(2)05351. It encodes a product with epidermal growth factor receptor activity involved in eye morphogenesis (sensu Drosophila) which is a component of the integral to plasma membrane; it is expressed in the adult (cerebral cortex, follicle cell, proventriculus and thoracic ganglion), embryo (apodeme, cellular blastoderm, celular blastoderm, cephalic furrow and 19 other listed tissues), larva (Malpighian tubule, antennal disc, dorsal mesothoracic disc, embryonic/larval salivary gland and 15 other listed tissues), ovary (follicle cell, nurse cell and oocyte) and prepupa and pupa (adult foregut, adult hindgut and adult fat body). It has been sequenced and its amino acid sequence contains an epidermal growth-factor receptor (EGFR), L domain, an eukaryotic protein kinase, a tyrosine kinase catalytic domain and a furin-like cysteine rich region. It has been mapped by recombination to 2-101 and cytologically to 57E9--F1. It interacts genetically with vn, ed, N, rho, Ras85D and 81 other listed genes. There are 139 recorded alleles: 27 in vitro constructs (2 available from the public stock centers), 111 classical mutants (6 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the somatic clone wing, the somatic clone leg, the somatic clone head and 8 other listed tissues and are embryonic recessive lethal, partially somatic clone cell lethal and recessive visible. Egfr is discussed in 835 references (excluding sequence accessions), dated between 1960 and 2004. These include at least 136 studies of mutant phenotypes, 33 studies of wild-type function and 15 molecular studies. Among findings on Egfr mutants, Egfr is necessary for proper wing venation, development of the arista, legs and female genital disc and mutations alter the distribution of macrochaetae. Among findings on Egfr function, Egfr signalling regulates ommatidial rotation and cell motility in the eye. (However, there is much more information on function so that may not be representative.)
The D. melanogaster gene Epidermal growth factor receptor, abbreviated as Egfr, is reported here. It has also been known in FlyBase as HD-33 and l(2)05351. It encodes a product with epidermal growth factor receptor activity involved in eye morphogenesis (sensu Drosophila) which is a component of the integral to plasma membrane; it is expressed in the adult (cerebral cortex, follicle cell, proventriculus and thoracic ganglion), embryo (apodeme, cellular blastoderm, celular blastoderm, cephalic furrow and 19 other listed tissues), larva (Malpighian tubule, antennal disc, dorsal mesothoracic disc, embryonic/larval salivary gland and 15 other listed tissues), ovary (follicle cell, nurse cell and oocyte) and prepupa and pupa (adult foregut, adult hindgut and adult fat body). It has been sequenced and its amino acid sequence contains an epidermal growth-factor receptor (EGFR), L domain, an eukaryotic protein kinase, a tyrosine kinase catalytic domain and a furin-like cysteine rich region. It has been mapped by recombination to 2-101 and cytologically to 57E9--F1. It interacts genetically with vn, ed, N, rho, Ras85D and 81 other listed genes. There are 139 recorded alleles: 27 in vitro constructs (2 available from the public stock centers), 111 classical mutants (6 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the somatic clone wing, the somatic clone leg, the somatic clone head and 8 other listed tissues and are embryonic recessive lethal, partially somatic clone cell lethal and recessive visible. Egfr is discussed in 835 references (excluding sequence accessions), dated between 1960 and 2004. These include at least 136 studies of mutant phenotypes, 33 studies of wild-type function and 15 molecular studies. Among findings on Egfr mutants, Egfr is necessary for proper wing venation, development of the arista, legs and female genital disc and mutations alter the distribution of macrochaetae. Among findings on Egfr function, Egfr signalling regulates ommatidial rotation and cell motility in the eye. (However, there is much more information on function so that may not be representative.)
As a farewell address at the end of his term, President Eisenhower - himself one of the greatest military generals of World War II - chose to give an explicit warning of the rising power of the Military Industrial Complex in American politics and society".
