Fly Gene: Egfr - XSLT v1 Table of UGP info with Summary

Submitted by mcaudy on Sat, 05/30/2009 - 23:54.
GeneID Name
FBgn0003731 Epidermal growth factor receptor
Molecular_function Biological_process Cellular_component
transmembrane receptor activity traceable author statement epidermal growth factor receptor activity inferred from sequence similarity epidermal growth factor receptor activity traceable author statement gurken receptor activity non-traceable author statement protein-tyrosine kinase activity ; ; EC:2.7.1.112 non-traceable author statement protein-tyrosine kinase activity ; ; EC:2.7.1.112 transmembrane receptor activity epidermal growth factor receptor activity gurken receptor activity epidermal growth factor receptor activity inferred from sequence similarity with UniProt:P00533 G2/M transition of mitotic cell cycle Malpighian tubule morphogenesis R7 differentiation antennal morphogenesis anterior/posterior pattern formation anti-apoptosis blastoderm segmentation border cell migration (sensu Insecta) brain development branch cell fate determination (sensu Insecta) cell fate commitment cell fate determination cell projection biogenesis compound eye morphogenesis (sensu Drosophila) cone cell fate commitment (sensu Drosophila) dorsal closure dorsal/ventral axis specification dorsal/ventral pattern formation eggshell pattern formation (sensu Insecta) embryonic axis specification embryonic pattern specification epidermal growth factor receptor signaling pathway eye morphogenesis (sensu Drosophila) female germ-line cyst encapsulation gastrulation germ-band shortening gurken receptor signaling pathway imaginal disc development imaginal disc pattern formation leg disc proximal/distal pattern formation male germ-line cyst encapsulation maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded (sensu Insecta) morphogenesis of an epithelium morphogenesis of follicular epithelium muscle attachment muscle cell fate specification negative regulation of retinal programmed cell death (sensu Drosophila) notum morphogenesis oenocyte differentiation ommatidial rotation oocyte anterior/posterior axis determination (sensu Insecta) oocyte anterior/posterior axis determination oocyte dorsal/ventral axis determination oogenesis (sensu Insecta) photoreceptor differentiation (sensu Drosophila) photoreceptor fate commitment (sensu Drosophila) progression of morphogenetic furrow (sensu Drosophila) protein amino acid phosphorylation regulation of R8 spacing regulation of mitotic cell cycle salivary gland development second mitotic wave (sensu Drosophila) stomatogastric nervous system development tracheal system development (sensu Insecta) wing disc metamorphosis wing disc proximal/distal pattern formation wing morphogenesis wing vein morphogenesis wing vein specification integral to plasma membrane plasma membrane
SUMMARY
The D. melanogaster gene Epidermal growth factor receptor, abbreviated as Egfr, is reported here. It has also been known in FlyBase as HD-33 and l(2)05351. It encodes a product with epidermal growth factor receptor activity involved in eye morphogenesis (sensu Drosophila) which is a component of the integral to plasma membrane; it is expressed in the adult (cerebral cortex, follicle cell, proventriculus and thoracic ganglion), embryo (apodeme, cellular blastoderm, celular blastoderm, cephalic furrow and 19 other listed tissues), larva (Malpighian tubule, antennal disc, dorsal mesothoracic disc, embryonic/larval salivary gland and 15 other listed tissues), ovary (follicle cell, nurse cell and oocyte) and prepupa and pupa (adult foregut, adult hindgut and adult fat body). It has been sequenced and its amino acid sequence contains an epidermal growth-factor receptor (EGFR), L domain, an eukaryotic protein kinase, a tyrosine kinase catalytic domain and a furin-like cysteine rich region. It has been mapped by recombination to 2-101 and cytologically to 57E9--F1. It interacts genetically with vn, ed, N, rho, Ras85D and 81 other listed genes. There are 139 recorded alleles: 27 in vitro constructs (2 available from the public stock centers), 111 classical mutants (6 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the somatic clone wing, the somatic clone leg, the somatic clone head and 8 other listed tissues and are embryonic recessive lethal, partially somatic clone cell lethal and recessive visible. Egfr is discussed in 835 references (excluding sequence accessions), dated between 1960 and 2004. These include at least 136 studies of mutant phenotypes, 33 studies of wild-type function and 15 molecular studies. Among findings on Egfr mutants, Egfr is necessary for proper wing venation, development of the arista, legs and female genital disc and mutations alter the distribution of macrochaetae. Among findings on Egfr function, Egfr signalling regulates ommatidial rotation and cell motility in the eye. (However, there is much more information on function so that may not be representative.)
»