Fly Gene: Egfr; XSLT v1 gives Unified Gene Page info only

Submitted by mcaudy on Sun, 05/31/2009 - 00:00.

FlyBase Gene: Egfr -- (Source: FlyBase)
Gene Summary for Egfr

BASIC_INFORMATION
GeneID: FBgn0003731
Symbol: Egfr
Full_name: Epidermal growth factor receptor
Species: Drosophila melanogaster
Synonyms: CG10079 CG10079 CG10079 CG10079 c-erbB flb: faint little ball top: torpedo DER torpedo l(2)57DEFa Elp top/flb Ellipse top/DER l(2)05351 Egf-r DER/top EGFr DER/faint little ball EGF-R torpedo/Egfr Ellipse torpedo Torpedo/DER EGFR DER-Ellipse Degfr D-Egf Torpedo/Egfr Der: Drosophila epidermal growth factor receptor homologue DmHD-33 DER flb egfr torpedo/DER Elp-1 Elp-B1 Elp-B1RB1 epidermal growth factor receptor DER/EGFR EGF Receptor EGF receptor EgfR Torpedo DER\torpedo EK2-6 Egf l(2)09261 dEGFR EGF-receptor dEGFR1 D-EGFR C-erb El: Ellipse HD-33 l(2)57EFa l(2)57Ea top flb Egfr Der faint little ball Drosophila epidermal growth factor receptor homologue
Date: 20 Aug 04
LOCATION
Chromosome: 2R
Genome_map: 16566556..16602978
Map: 57E9--F1 (cytogenetic)
Scaffold: AE003454
GENE_PRODUCT
Transcripts: Egfr-RA Egfr-PA (1377 aa)
, Egfr-RB Egfr-PB (1426 aa)
,
GENE_ONTOLOGY
Molecular_function: transmembrane receptor activity traceable author statement , epidermal growth factor receptor activity inferred from sequence similarity , epidermal growth factor receptor activity traceable author statement , gurken receptor activity non-traceable author statement , protein-tyrosine kinase activity ; ; EC:2.7.1.112 non-traceable author statement , protein-tyrosine kinase activity ; ; EC:2.7.1.112, transmembrane receptor activity, epidermal growth factor receptor activity, gurken receptor activity, epidermal growth factor receptor activity inferred from sequence similarity with UniProt:P00533 ,
Biological_process: G2/M transition of mitotic cell cycle, Malpighian tubule morphogenesis, R7 differentiation, antennal morphogenesis, anterior/posterior pattern formation, anti-apoptosis, blastoderm segmentation, border cell migration (sensu Insecta), brain development, branch cell fate determination (sensu Insecta), cell fate commitment, cell fate determination, cell projection biogenesis, compound eye morphogenesis (sensu Drosophila), cone cell fate commitment (sensu Drosophila), dorsal closure, dorsal/ventral axis specification, dorsal/ventral pattern formation, eggshell pattern formation (sensu Insecta), embryonic axis specification, embryonic pattern specification, epidermal growth factor receptor signaling pathway, eye morphogenesis (sensu Drosophila), female germ-line cyst encapsulation, gastrulation, germ-band shortening, gurken receptor signaling pathway, imaginal disc development, imaginal disc pattern formation, leg disc proximal/distal pattern formation, male germ-line cyst encapsulation, maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded (sensu Insecta), morphogenesis of an epithelium, morphogenesis of follicular epithelium, muscle attachment, muscle cell fate specification, negative regulation of retinal programmed cell death (sensu Drosophila), notum morphogenesis, oenocyte differentiation, ommatidial rotation, oocyte anterior/posterior axis determination (sensu Insecta), oocyte anterior/posterior axis determination, oocyte dorsal/ventral axis determination, oogenesis (sensu Insecta), photoreceptor differentiation (sensu Drosophila), photoreceptor fate commitment (sensu Drosophila), progression of morphogenetic furrow (sensu Drosophila), protein amino acid phosphorylation, regulation of R8 spacing, regulation of mitotic cell cycle, salivary gland development, second mitotic wave (sensu Drosophila), stomatogastric nervous system development, tracheal system development (sensu Insecta), wing disc metamorphosis, wing disc proximal/distal pattern formation, wing morphogenesis, wing vein morphogenesis, wing vein specification,
Cellular_component: integral to plasma membrane, plasma membrane,
FUNCTION
Expressions: adult genital disc imaginal disc larval brain ovary embryo larval brain dorsal mesothoracic disc nurse cell ectoderm stomodeum labral segment embryonic gnathal segment embryonic/larval midgut embryonic/larval proventriculus embryonic/larval fat body embryonic/larval pharynx cephalic furrow ventral midline larva eye-antennal disc oocyte celular blastoderm mesoderm embryonic/larval posterior spiracle antennal disc oogenesis follicle cell pupa imaginal disc pupa, adult embryonic telson
Protein_domains: IPR000494 == Epidermal growth-factor receptor (EGFR), L domain, IPR000719 == Eukaryotic protein kinase, IPR001245 == Tyrosine kinase catalytic domain, IPR002174 == Furin-like cysteine rich region, SCOP:48695 == Multiheme cytochromes; Egfr|FBgn0003731|pp-CT28361|FBan0010079, SCOP:52058 == L domain-like; Egfr|FBgn0003731|pp-CT28361|FBan0010079, SCOP:56112 == Protein kinase-like (PK-like); Egfr|FBgn0003731|pp-CT28361|FBan0010079, SCOP:57184 == IGF binding domain; Egfr|FBgn0003731|pp-CT28361|FBan0010079,
External_links: BDGPisx:Egfr, DEDB:1232, FlyGRID:FBgn0003731, IFly:../torstoll/egf-r1.htm, NCBI_GEO:FBgn0003731,
LITERATURE
Reference: FBrf0155681 Affolter et al. 2003 Dev. Cell 4(1): 11--18 Tube or not tube. Remodeling epithelial tissues by branching morphogenesis. Review
Reference: FBrf0158927 Shilo 2003 Exp. Cell Res. 284(1): 140--149 Signaling by the Drosophila epidermal growth factor receptor pathway during development. Review
Reference: FBrf0158727 de Celis 2003 BioEssays 25(5): 443--451 Pattern formation in the Drosophila wing: the development of the veins. Review
SUMMARY
The D. melanogaster gene Epidermal growth factor receptor, abbreviated as Egfr, is reported here. It has also been known in FlyBase as HD-33 and l(2)05351. It encodes a product with epidermal growth factor receptor activity involved in eye morphogenesis (sensu Drosophila) which is a component of the integral to plasma membrane; it is expressed in the adult (cerebral cortex, follicle cell, proventriculus and thoracic ganglion), embryo (apodeme, cellular blastoderm, celular blastoderm, cephalic furrow and 19 other listed tissues), larva (Malpighian tubule, antennal disc, dorsal mesothoracic disc, embryonic/larval salivary gland and 15 other listed tissues), ovary (follicle cell, nurse cell and oocyte) and prepupa and pupa (adult foregut, adult hindgut and adult fat body). It has been sequenced and its amino acid sequence contains an epidermal growth-factor receptor (EGFR), L domain, an eukaryotic protein kinase, a tyrosine kinase catalytic domain and a furin-like cysteine rich region. It has been mapped by recombination to 2-101 and cytologically to 57E9--F1. It interacts genetically with vn, ed, N, rho, Ras85D and 81 other listed genes. There are 139 recorded alleles: 27 in vitro constructs (2 available from the public stock centers), 111 classical mutants (6 available from the public stock centers) and 1 wild-type. Amorphic mutations have been isolated which affect the somatic clone wing, the somatic clone leg, the somatic clone head and 8 other listed tissues and are embryonic recessive lethal, partially somatic clone cell lethal and recessive visible. Egfr is discussed in 835 references (excluding sequence accessions), dated between 1960 and 2004. These include at least 136 studies of mutant phenotypes, 33 studies of wild-type function and 15 molecular studies. Among findings on Egfr mutants, Egfr is necessary for proper wing venation, development of the arista, legs and female genital disc and mutations alter the distribution of macrochaetae. Among findings on Egfr function, Egfr signalling regulates ommatidial rotation and cell motility in the eye. (However, there is much more information on function so that may not be representative.)


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